Neider M W, Crawford K, Kaufman P L, Bito L Z
Department of Ophthalmology, University of Wisconsin, Madison.
Arch Ophthalmol. 1990 Jan;108(1):69-74. doi: 10.1001/archopht.1990.01070030075032.
Fourteen rhesus monkeys, aged 1 to 24 years, underwent permanent implantation of a bipolar stimulating electrode into the Edinger-Westphal nucleus and complete unilateral or bilateral iridectomy. Slit-lamp Scheimpflug videography of the lens and slit-lamp goniovideography of the lens equator, zonule, and ciliary body allowed direct real-time observation and video recording of the movements of these structures during centrally stimulated accommodation and during disaccommodation. Scalloping of the lens capsule at the zonular insertion sites was clearly visible during disaccommodation and even during accommodation when the zonules were folded. During accommodation, the lens became axially thicker, the ciliary ring narrowed, and, at high levels of accommodation, the zonular fibers slackened and even folded and the lens moved downward. With increasing age and concomitantly decreasing accommodative amplitude, these excursions all diminished, so that in the oldest animals, they were very minimal or absent. Maximum centrally stimulated accommodative amplitude declined with age on a time scale similar to that for cholinomimetic drug-induced accommodation in the rhesus monkey and voluntary accommodation in the human.
十四只年龄在1至24岁的恒河猴接受了将双极刺激电极永久性植入动眼神经副核以及完全单侧或双侧虹膜切除术。通过裂隙灯Scheimpflug晶状体摄像以及晶状体赤道、悬韧带和睫状体的裂隙灯房角摄像，可以在中枢刺激调节和放松调节期间对这些结构的运动进行直接实时观察和视频记录。在放松调节期间，甚至在悬韧带折叠的调节期间，都能清楚地看到晶状体囊在悬韧带插入部位的扇贝样改变。在调节期间，晶状体轴向变厚，睫状环变窄，在高调节水平时，悬韧带纤维松弛甚至折叠，晶状体向下移动。随着年龄的增长以及随之而来的调节幅度减小，这些偏移都减小了，以至于在最老的动物中，它们非常微小或不存在。中枢刺激的最大调节幅度随年龄下降的时间尺度与恒河猴中拟胆碱药物诱导的调节以及人类的自主调节相似。
