幽门螺杆菌诊断检测的诊断价值：粪便抗原检测、尿素呼气试验、快速尿素酶试验、血清学检测和组织学检测。
Diagnostic values of Helicobacter pylori diagnostic tests: stool antigen test, urea breath test, rapid urease test, serology and histology.
作者信息
Kazemi Shadi, Tavakkoli Hamid, Habizadeh Mohamad Reza, Emami Mohammad Hasan
机构信息
Internal Medicine Resident, Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2011 Sep;16(9):1097-104.
BACKGROUND
The purpose of this study is to compare validity of 5 diagnostic tests of helicobacter pylori with each other: stool antigen test, urea breath test (UBT), rapid urease test (RUT), serology and histology.
METHODS
A total of 94 patients who had indication of endoscopy entered the study. All of the 5 tests were performed for each patient. When the results of at least 2 tests were positive (except serology), Helicobacter pylori infection was considered to be positive. The sensitivity, specificity, positive predictive value, negative predictive value, accuracy and area under receiver operating characteristic (ROC) curve of these 5 tests were determined.
RESULTS
The sensitivity, specificity, positive predictive value, negative predictive value, accuracy and area under ROC curve of these 5 tests are as below, respectively.
HISTOLOGY
89%, 78%, 93%, 91%, 85% and 0.881; RUT: 93%, 75%, 95%, 94%, 86% and 0.831; serology: 50%, 54%, 46%, 61%, 52% and 0.563; stool antigen test: 96%, 83%, 98%, 96%, 91% and 0.897; UBT: 89%, 73%, 92%, 90%, 82% and 0.892.
CONCLUSIONS
Stool antigen test is the most accurate test for Helicobacter pylori diagnosis before eradication of these bacteria.
背景
本研究旨在比较幽门螺杆菌5种诊断检测方法之间的有效性：粪便抗原检测、尿素呼气试验（UBT）、快速尿素酶试验（RUT）、血清学检测和组织学检测。
方法
共有94例有内镜检查指征的患者进入本研究。对每位患者进行所有5种检测。当至少2种检测结果为阳性时（血清学检测除外），则认为幽门螺杆菌感染呈阳性。确定这5种检测的敏感性、特异性、阳性预测值、阴性预测值、准确性以及受试者操作特征（ROC）曲线下面积。
结果
这5种检测的敏感性、特异性、阳性预测值、阴性预测值、准确性以及ROC曲线下面积分别如下。
组织学检测
89%、78%、93%、91%、85%和0.881；快速尿素酶试验：93%、75%、95%、94%、86%和0.831；血清学检测：(50%)、(54%)、(46%)、(61%)、(52%)和0.563；粪便抗原检测：96%、83%、98%．96%、91%和0.897；尿素呼气试验：89%、73%、92%、90%、82%和0.892。
结论
在根除幽门螺杆菌之前，粪便抗原检测是诊断幽门螺杆菌最准确的检测方法。
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