Hashemipour Mahin, Rostampour Noushin, Nasry Peyman, Hovsepian Silva, Basiratnia Reza, Hekmatnia Ali, Shahkarami Amir Hossein, Mehrabi Ali, Hadian Rezvane, Amini Massoud
Professor of Pediatric Endocrinology, Endocrine & Metabolism Research Center, Child Health Promotion Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2011 Sep;16(9):1122-8.
The aim of this study was to compare the usefulness of ultrasonography and scintigraphy in diagnosing the etiology of primary congenital hypothyroidism (CH).
The newborns that were examined by both thyroid scintigraphy and ultrasonography during CH screening program in Isfahan were included in this study. The ultrasonographic findings were compared with the scintigraphic findings and the sensitivity and specificity of the ultrasonography was determined.
During this study, 102 CH newborns were studied. According to the ultrasonographic results, 61.8%, 26.5%, 2.9% and 8.8% of them had normal thyroid gland, agenesia, ectopia and hypoplasia, respectively, and according to scintigraphic results, 55.9%, 35.3% and 8.8% of them had normal thyroid gland, agenesia and ectopia, respectively. Ultrasound detected sensitivity, specificity, positive predictive value, negative predictive value, and positive and negative likelihood ratio were 77%, 92%, 89%, 84%, 9.6 and 0.25, respectively. The sensitivity and specificity of ultrasonography compared with thyroid scintigraphy in diagnosis of thyroid gland ectopia was 33% and 100%, respectively.
Though thyroid ultrasonography failed to diagnose 67% of ectopic cases and nonfunctioning thyroid gland, it had the ability to determine the anatomy of thyroid gland. So, considering some limitations of scintigraphy, we concluded that ultrasonography is a relatively appropriate imaging tool for diagnosing CH etiologies, especially in the initial phase of CH screening.
本研究旨在比较超声检查和闪烁扫描术在诊断原发性先天性甲状腺功能减退症（CH）病因方面的效用。
纳入在伊斯法罕进行CH筛查项目期间接受甲状腺闪烁扫描术和超声检查的新生儿。将超声检查结果与闪烁扫描术结果进行比较，并确定超声检查的敏感性和特异性。
在本研究期间，对102例CH新生儿进行了研究。根据超声检查结果，其中61.8%、26.5%、2.9%和8.8%的新生儿甲状腺正常、缺如、异位和发育不全，而根据闪烁扫描术结果，分别有55.9%、35.3%和8.8%的新生儿甲状腺正常、缺如和异位。超声检查的检测敏感性、特异性、阳性预测值、阴性预测值以及阳性和阴性似然比分别为77%、92%、89%、84%、9.6和0.25。超声检查与甲状腺闪烁扫描术相比，在诊断甲状腺异位方面的敏感性和特异性分别为33%和100%。
尽管甲状腺超声检查未能诊断出67%的异位病例和无功能甲状腺，但它有能力确定甲状腺的解剖结构。因此，考虑到闪烁扫描术的一些局限性，我们得出结论，超声检查是诊断CH病因的一种相对合适的成像工具，尤其是在CH筛查的初始阶段。
