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从一名感染性心内膜炎患者分离出的金黄色葡萄球菌小菌落变异株:病例报告及文献复习

Small Colony variants of Staphylococcus aureus isolated from a patient with infective endocarditis: a case report and review of the literature.

作者信息

Bhattacharyya S, Roy S, Mukhopadhyay Pk, Rit K, Dey Jb, Ganguly U, Ray R

机构信息

Department of Microbiology, Bankura Sammilani Medical College, Bankura, West Bengal, India.

出版信息

Iran J Microbiol. 2012 Jun;4(2):98-9.

PMID:22973477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3434649/
Abstract

Staphylococcus aureus produces a particular morphological variant called small colony variant (SCV) which is responsible for persistent subclinical infections in predisposed individuals and is usually resistant to aminoglycosides and cell wall active antibiotics. Infections by SCV of S. aureus are an upcoming problem due to difficulty in laboratory diagnosis and resistance to antimicrobial chemotherapy. We here report a case of infective endocarditis caused by SCV of Staphylococcus aureus in a pediatric patient.

摘要

金黄色葡萄球菌会产生一种特殊的形态变异体,称为小菌落变异体(SCV),它会导致易感个体发生持续性亚临床感染,并且通常对氨基糖苷类药物和细胞壁活性抗生素耐药。由于实验室诊断困难以及对抗菌化疗耐药,金黄色葡萄球菌SCV引起的感染正成为一个新出现的问题。我们在此报告一例儿科患者由金黄色葡萄球菌SCV引起的感染性心内膜炎病例。

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2
Staphylococcus aureus as an intracellular pathogen: the role of small colony variants.金黄色葡萄球菌作为一种细胞内病原体:小菌落变体的作用。
Trends Microbiol. 2009 Feb;17(2):54-8. doi: 10.1016/j.tim.2008.11.004. Epub 2009 Jan 21.
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Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B.金黄色葡萄球菌小菌落变异株对抗菌肽乳铁蛋白B具有抗性。
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Small colony variants of Staphylococcus aureus and pacemaker-related infection.金黄色葡萄球菌小菌落变异株与起搏器相关感染
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Thymidine-dependent small-colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separation.金黄色葡萄球菌的胸腺嘧啶核苷依赖性小菌落变体表现出与细胞分离受损一致的总体形态和超微结构变化。
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