血清同型半胱氨酸和叶酸浓度在美国青少年队列中叶酸强化前后的变化。

Serum homocysteine and folate concentrations among a US cohort of adolescents before and after folic acid fortification.

机构信息

Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite #1360, Seattle, WA 98101, USA.

出版信息

Public Health Nutr. 2012 Oct;15(10):1818-26. doi: 10.1017/S1368980012002984.

DOI:10.1017/S1368980012002984

PMID:22974678

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3638807/

Abstract

OBJECTIVE

We assessed serum homocysteine (tHcy) and folate concentrations among US adolescents before and after fortification of cereal-grain products with folic acid, and associations with demographic, behavioural and physiological factors.

DESIGN

Observational study conducted among participants of a randomized trial.

SETTING

The Child and Adolescent Trial for Cardiovascular Health (CATCH) study.

SUBJECTS

Adolescents (n 2445) in grades 8 (pre-fortification, mean age 14 years) and 12 (post-fortification, mean age 18 years).

RESULTS

Average serum concentrations of tHcy, folate and vitamin B6 increased by 17 %, 16 % and 14 %, respectively, while serum concentrations of vitamin B12 decreased by 11 % post-fortification. Folic acid fortification provided, on average, an additional intake of 118 μg folate/d. Male sex (P < 0.0001) and white race (P = 0.0008) were associated with significantly greater increases in tHcy concentration, while increases in BMI (P = 0.006) and serum folate concentration (P < 0.0001) were associated with significant decreases in tHcy concentration. Female sex (P < 0.0001), non-smoking (P < 0.0001), use of multivitamins (P < 0.0001) and higher dietary intake of folate (P = 0.001) were associated with significantly greater increases in serum folate concentrations. From grade 8 to grade 12, the upward age trend in serum tHcy concentration was uninterrupted in its course (P > 0.50); whereas serum folic acid concentration showed a downward trend that incurred a discrete jump upward (17 % higher; P < 0.0001) with fortification. These trends differed significantly for males v. females (P < 0.001 for interaction).

CONCLUSIONS

Fortification had a significant impact on improving folate status but not serum tHcy concentrations among US adolescents.

摘要

目的

我们评估了美国青少年在强化谷物产品叶酸前后血清同型半胱氨酸（tHcy）和叶酸浓度，并分析了其与人口统计学、行为和生理因素的关系。

设计

在一项随机试验中对参与者进行的观察性研究。

设置

儿童和青少年心血管健康试验（CATCH）研究。

受试者

8 年级（强化前，平均年龄 14 岁）和 12 年级（强化后，平均年龄 18 岁）的青少年（n=2445）。

结果

tHcy、叶酸和维生素 B6 的血清平均浓度分别增加了 17%、16%和 14%，而维生素 B12 的血清浓度则降低了 11%。叶酸强化平均提供了 118μg/d 的额外叶酸摄入。男性（P<0.0001）和白人种族（P=0.0008）与 tHcy 浓度的显著增加有关，而 BMI 的增加（P=0.006）和血清叶酸浓度的增加（P<0.0001）与 tHcy 浓度的显著降低有关。女性（P<0.0001）、不吸烟（P<0.0001）、使用多种维生素（P<0.0001）和较高的膳食叶酸摄入（P=0.001）与血清叶酸浓度的显著增加有关。从 8 年级到 12 年级，血清 tHcy 浓度的上升年龄趋势在整个过程中没有中断（P>0.50）；而叶酸浓度呈下降趋势，在强化后出现了明显的上升（增加 17%；P<0.0001）。这些趋势在男性和女性之间存在显著差异（P<0.001，交互作用）。