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灰黄青霉变种和少根根霉对孕酮的生物转化。

Biotransformation of progesterone by Absidia griseolla var. igachii and Rhizomucor pusillus.

机构信息

Department of Chemistry, Faculty of Science, Shahid Beheshti University, G.C., Tehran, Iran.

出版信息

Steroids. 2012 Nov;77(13):1446-9. doi: 10.1016/j.steroids.2012.08.010. Epub 2012 Sep 3.

DOI:10.1016/j.steroids.2012.08.010
PMID:22974825
Abstract

Biotransformation of progesterone using Absidia griseolla var. igachii and Rhizomucor pusillus strains as biocatalysts were investigated. Microbial hydroxylation of progesterone by A. griseolla produced two hydroxylated pregnane-like steroids. The metabolites identified as 6β,14α-dihydroxyprogesterone and 7α,14α-dihydroxyprogesterone. R. pusillus produced 6β,11α-dihydroxyprogesterone with excellent yield (65.5%) and 7α,14α-dihydroxyprogesterone. These metabolites were purified by TLC followed by their identification through (1)H, (13)C NMR and other spectroscopic data.

摘要

利用灰绿曲霉变种和米根霉作为生物催化剂对孕酮进行生物转化的研究。微生物对孕酮的羟化作用使 A. griseolla 产生了两种羟化孕烷类甾体。鉴定出的代谢产物为 6β,14α-二羟基孕酮和 7α,14α-二羟基孕酮。R. pusillus 以优异的产率（65.5%）产生 6β,11α-二羟基孕酮和 7α,14α-二羟基孕酮。这些代谢产物通过 TLC 进行纯化，然后通过（1）H、（13）C NMR 和其他光谱数据进行鉴定。

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