Clermont Université, Université d'Auvergne, Centre de Recherche en Nutrition Humaine Auvergne, EA 4678 CIDAM, Conception, Ingénierie et Développement de l'Aliment et du Médicament, BP10448, F-63000 Clermont-Ferrand, France.
Trends Biotechnol. 2012 Nov;30(11):591-600. doi: 10.1016/j.tibtech.2012.08.001. Epub 2012 Sep 10.
Gastric and small intestinal (GSI) models are increasingly used as an alternative to in vivo assays to answer many questions raised by industry and researchers. A broad range of in vitro systems is available, from static monocompartmental to dynamic multicompartmental models. However, these models require a compromise between technological complexity and biological significance. Further efforts and technological innovations are still needed to improve in vitro models and meet growing demands in the areas of nutrition and health. This review describes the models available to date for the human stomach and small intestine and highlights their relevance in nutritional, toxicological, pharmaceutical, and microbiological studies. Limitations and challenges facing artificial digestion technology are also discussed.
胃和小肠（GSI）模型越来越多地被用作替代体内测定法，以回答行业和研究人员提出的许多问题。有广泛的体外系统可供选择，从静态单室到动态多室模型。然而，这些模型需要在技术复杂性和生物学意义之间进行权衡。仍然需要进一步的努力和技术创新，以改进体外模型，并满足营养和健康领域不断增长的需求。本综述描述了目前用于人类胃和小肠的模型，并强调了它们在营养、毒理学、药物和微生物学研究中的相关性。还讨论了人工消化技术面临的局限性和挑战。
