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矛头蝮蛇（Hypnale hypnale）毒液导致的肾毒性可被异源的血宝多价抗蛇毒血清（HPA）预防。

Nephrotoxicity of hump-nosed pit viper (Hypnale hypnale) venom in mice is preventable by the paraspecific Hemato polyvalent antivenom (HPA).

机构信息

Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

Toxicon. 2012 Dec 1;60(7):1259-62. doi: 10.1016/j.toxicon.2012.08.012. Epub 2012 Sep 5.

DOI:10.1016/j.toxicon.2012.08.012
PMID:22975088
Abstract

Mice experimentally envenomed with Hypnale hypnale venom (1× and 1.5×LD₅₀) developed acute kidney injury (AKI) principally characterized by raised blood urea and creatinine. Prolonged blood clotting time and hemorrhage in lungs implied bleeding tendency. Pallor noted in most renal cortices was suggestive of renal ischemia secondary to consumptive coagulopathy. Intravenous infusion of Hemato polyvalent antivenom following experimental envenoming effectively prevented death and AKI in all mice, supporting its potential therapeutic use in envenoming cases.

摘要

实验性地用 Hypnale hypnale 毒液（1× 和 1.5×LD₅₀）中毒的老鼠发展为急性肾损伤（AKI），主要表现为血尿素和肌酐升高。凝血时间延长和肺部出血表明有出血倾向。大多数肾皮质出现苍白提示继发于消耗性凝血障碍的肾缺血。实验性中毒后静脉输注 Hemato 多价抗蛇毒血清有效地预防了所有老鼠的死亡和 AKI，支持其在蛇伤病例中的潜在治疗用途。

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