Grupo de Materiais Poliméricos e Compósitos, GMPC - Departamento de Química, Universidade Estadual de Maringá UEM - Av. Colombo 5790 - CEP 87020-900 Maringá, Paraná, Brazil.
Int J Biol Macromol. 2012 Dec;51(5):1127-33. doi: 10.1016/j.ijbiomac.2012.08.032. Epub 2012 Sep 2.
This work deals with the preparation of chitosan/tripolyphosphate microparticles (CHT/TPP) using microemulsion system based on water/benzyl alcohol. The morphology of the microparticles was evaluated by scanning electron microscopy (SEM). The microparticles were also characterized through infrared spectroscopy (FTIR) and wide-angle X-ray scattering (WAXS). The morphology and crystallinity of microparticles depended mainly on CHT/TPP ratio. Studies of controlled release of HP were evaluated in distilled water and in simulated gastric fluid. Besides, the profile of HP releasing could be tailored by tuning the CHT/TPP molar ratio. Finally, these prospective results allow the particles to be employed as site-specific HP controlled release system.
本工作采用基于水/苄醇的微乳液体系制备壳聚糖/三聚磷酸钠（CHT/TPP）微球。通过扫描电子显微镜（SEM）评估了微球的形态。通过红外光谱（FTIR）和广角 X 射线散射（WAXS）对微球进行了表征。微球的形态和结晶度主要取决于 CHT/TPP 的比例。在蒸馏水和模拟胃液中评价了 HP 的控制释放研究。此外，可以通过调整 CHT/TPP 的摩尔比来调整 HP 释放的形态。最后，这些有前景的结果使得这些颗粒可以作为 HP 控释的特定部位释放系统。
