Sánchez-Serrano Samuel, González-Méndez Daniela J, Olivas-Valdez José A, Millán-Aguiñaga Natalie, Evangelista Viridiana, Contreras Oscar E, Cardoza-Contreras Marlene N
Marine Sciences Faculty, Autonomous University of Baja California, Ensenada 22860, Mexico.
Nanosciences and Nanotechnology Center, National Autonomus University of Mexico, Ensenada 22800, Mexico.
Polymers (Basel). 2023 Oct 16;15(20):4105. doi: 10.3390/polym15204105.
In this study, we synthesized and characterized pH-responsive Chitosan-AgCl-doped ZnO hybrid hydrogels and evaluated their potential for loading aquaculture bioactive compounds, and assessed their antimicrobial properties against a threatening pathogen associated with disease across a broad spectrum of warm water fish and invertebrates. Hydrogel characterization consisted of assessing morphology via SEM, composition via EDS, hydrogels' network components interactions via FT-IR and pH response through swelling behavior determinations. The swelling characterization of the synthesized hydrogels demonstrated a pH-responsive behavior, showing that low pH values caused the hydrogel polymeric network to expand and capture more of the aqueous solution. These characteristics make the synthesized hydrogels suitable for the encapsulation and controlled release of drugs and bioactive compounds in aquaculture. Chitosan_ZnO hybrid hydrogels showed great antimicrobial activity against , even better than that of loaded PB hydrogels. Here, we provide evidence for the potential capacity of Chitosan_ZnO hybrid hydrogels for the preventive and curative treatment of diseases that impact aquaculture animal health and prevent drug resistance by bacteria.
在本研究中，我们合成并表征了pH响应性壳聚糖 - 氯化银掺杂的氧化锌杂化水凝胶，评估了它们负载水产养殖生物活性化合物的潜力，并评估了它们对广泛的温水鱼类和无脊椎动物中与疾病相关的威胁性病原体的抗菌性能。水凝胶表征包括通过扫描电子显微镜（SEM）评估形态、通过能谱分析（EDS）分析组成、通过傅里叶变换红外光谱（FT-IR）分析水凝胶网络成分的相互作用以及通过溶胀行为测定分析pH响应。合成水凝胶的溶胀表征显示出pH响应行为，表明低pH值会导致水凝胶聚合物网络膨胀并捕获更多水溶液。这些特性使合成水凝胶适用于水产养殖中药物和生物活性化合物的包封和控释。壳聚糖 - 氧化锌杂化水凝胶对……显示出很强的抗菌活性，甚至比负载PB的水凝胶更好。在此，我们提供证据证明壳聚糖 - 氧化锌杂化水凝胶在预防和治疗影响水产养殖动物健康的疾病以及防止细菌产生耐药性方面的潜在能力。
