如何微调一个表观遗传开关。

How to fine-tune an epigenetic switch.

机构信息

Institute of Plant Biology and Zürich-Basel Plant Science Center, University of Zürich, CH-8008 Zürich, Switzerland.

出版信息

Dev Cell. 2012 Sep 11;23(3):453-4. doi: 10.1016/j.devcel.2012.08.014.

DOI:10.1016/j.devcel.2012.08.014

Abstract

Arabidopsis does not flower in winter because FLC represses flowering genes, but prolonged cold exposure silences FLC, allowing flowering in spring. How do plants recalibrate this switch to adapt to different climates? Reporting in Science, Coustham et al. (2012) found that tweaking a Polycomb target sequence may do the trick.

摘要

拟南芥在冬季不开花，因为 FLC 抑制开花基因，但长时间的寒冷会使 FLC 沉默，从而在春季开花。植物如何重新调整这个开关以适应不同的气候？考斯特姆等人在《科学》杂志上报告（2012 年）发现，调整一个 Polycomb 靶序列可能是个好办法。