IgG4相关性肾小管间质性肾炎：两例病例报告及文献综述

IgG4-associated tubulointerstitial nephritis: two case reports and a literature review.

作者信息

Fang Yi, Hou Jun, Cai Fengqing, Ding Xiaoqiang, Liu Hong

机构信息

Department of Nephrology, Zhongshan Hospital, Shanghai Fudan University, China.

出版信息

Intern Med. 2012;51(17):2385-91. doi: 10.2169/internalmedicine.51.7970. Epub 2012 Sep 1.

DOI:10.2169/internalmedicine.51.7970

PMID:22975554

Abstract

IgG4-related systemic disease (IgG4-RSD) is an autoimmune disease that includes a wide variety of lesions. IgG4-RSD is characterized by high levels of serum IgG4, abundant levels of IgG4-positive plasma cells and T-lymphocyte infiltration in various organs. Tubulointerstitial nephritis (TIN) is a major finding when the kidneys are involved and is effectively treated with corticosteroid therapy. We herein describe two cases of IgG4-related TIN. Such cases have rarely been reported in China.

摘要

IgG4相关性系统性疾病（IgG4-RSD）是一种自身免疫性疾病，包含多种病变。IgG4-RSD的特征为血清IgG4水平升高、IgG4阳性浆细胞数量丰富以及各器官出现T淋巴细胞浸润。当肾脏受累时，肾小管间质性肾炎（TIN）是主要表现，采用皮质类固醇疗法可有效治疗。我们在此描述两例IgG4相关性TIN。此类病例在中国鲜有报道。