Kunimasa Kei, Ishida Tadashi, Kimura Soichiro, Tanaka Maki, Kouyama Yuichi, Yamashita Shigeki, Morita Mitsunori, Tachibana Hiromasa, Tokioka Fumiaki, Ito Akihiro, Sumi Chisato, Tateda Kazuhiro
Department of Respiratory Medicine, Kurashiki Central Hospital, Japan.
Intern Med. 2012;51(17):2473-8. doi: 10.2169/internalmedicine.51.7596. Epub 2012 Sep 1.
This report presents a case of fulminant community-acquired Pseudomonas aeruginosa necrotizing pneumonia in a previously healthy young man, including an analysis of the virulence of the P.aeruginosa isolated from the patient. The patient was successfully treated with intensive care and antibiotic treatment. This study analyzed the pathogenicity of the isolated strain both in vivo (using a mouse pneumonia model) and in vitro (using biofilm production), but could not explain how an otherwise healthy young man developed such severe community-acquired P.aeruginosa pneumonia. Although rare in community-acquired pneumonia, P.aeruginosa infection should be considered in patients with severe rapidly progressive pneumonia.
本报告介绍了一例先前健康的年轻男性患暴发性社区获得性铜绿假单胞菌坏死性肺炎的病例，包括对从患者分离出的铜绿假单胞菌的毒力分析。该患者通过重症监护和抗生素治疗成功治愈。本研究分析了分离菌株在体内（使用小鼠肺炎模型）和体外（使用生物膜形成）的致病性，但无法解释一名原本健康的年轻男性如何患上如此严重的社区获得性铜绿假单胞菌肺炎。尽管铜绿假单胞菌感染在社区获得性肺炎中很少见，但对于患有严重快速进展性肺炎的患者应考虑这种感染。
