New treatments for CKD--new insights into pathogenesis.
作者信息
Lederer Eleanor D, Klein Jon B
出版信息
J Am Soc Nephrol. 2012 Oct;23(10):1601-3. doi: 10.1681/ASN.2012080842. Epub 2012 Sep 13.
Abstract
摘要
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本文引用的文献
1
Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.Bardoxolone 甲酯可降低肾脏中的 megalin 并激活 Nrf2。
J Am Soc Nephrol. 2012 Oct;23(10):1663-73. doi: 10.1681/ASN.2012050457. Epub 2012 Aug 2.
2
Vitamin D: roles in renal and cardiovascular protection.维生素 D：在肾脏和心血管保护中的作用。
Curr Opin Nephrol Hypertens. 2012 Jan;21(1):72-9. doi: 10.1097/MNH.0b013e32834de4ee.
3
Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy.Nrf2 激活剂在链脲佐菌素诱导的糖尿病肾病中的治疗潜力。
Diabetes. 2011 Nov;60(11):3055-66. doi: 10.2337/db11-0807.
4
Bardoxolone methyl and kidney function in CKD with type 2 diabetes.巴多索隆甲和 2 型糖尿病 CKD 患者的肾功能。
N Engl J Med. 2011 Jul 28;365(4):327-36. doi: 10.1056/NEJMoa1105351. Epub 2011 Jun 24.
5
Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.重新审视肾内肾素-血管紧张素系统：沿近端肾单位的巨球蛋白依赖内吞作用的作用。
J Biol Chem. 2010 Dec 31;285(53):41935-46. doi: 10.1074/jbc.M110.150284. Epub 2010 Oct 21.
6
The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy.Nrf2 在链脲佐菌素诱导的糖尿病肾病中的保护作用。
Diabetes. 2010 Apr;59(4):850-60. doi: 10.2337/db09-1342. Epub 2010 Jan 26.
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Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.巨膜蛋白在非选择性蛋白尿期间促成近端小管细胞的早期损伤。
Kidney Int. 2008 Nov;74(10):1262-9. doi: 10.1038/ki.2008.405. Epub 2008 Sep 3.
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Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injury.通过缺乏巨蛋白的近端肾小管消除蛋白质摄取并不能预防肾小管间质损伤。
J Am Soc Nephrol. 2007 Jun;18(6):1824-34. doi: 10.1681/ASN.2006111266. Epub 2007 Apr 25.
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PKB and megalin determine the survival or death of renal proximal tubule cells.蛋白激酶B和巨蛋白决定肾近端小管细胞的存活或死亡。
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18810-5. doi: 10.1073/pnas.0605029103. Epub 2006 Nov 22.
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Regulated intramembrane proteolysis of megalin: linking urinary protein and gene regulation in proximal tubule?巨膜蛋白的调节性膜内蛋白水解：近端小管中尿蛋白与基因调节的联系？
Kidney Int. 2006 May;69(10):1717-21. doi: 10.1038/sj.ki.5000298.
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