Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.
Clin Hemorheol Microcirc. 2012;52(2-4):131-9. doi: 10.3233/CH-2012-1591.
Macrohemodynamic targets such as mean arterial pressure, cardiac output, and mixed or central venous oxygen saturation have been used to guide treatment of patients presenting circulatory shock. However, it has been shown that despite of improvement of macrocirculatory parameters there is persisting microcirculatory dysfunction. The restoration of microvascular perfusion in order to improve oxygenation, prevent tissue hypoxia, and maintain organ function represents the main aim of hemodynamic resuscitation. Therefore, microcirculatory targets may represent the most important endpoints to optimize therapy of circulatory shock.
宏观血流动力学目标，如平均动脉压、心输出量和混合或中心静脉血氧饱和度，已被用于指导循环休克患者的治疗。然而，已经表明，尽管宏观血流动力学参数得到改善，但仍存在持续的微循环功能障碍。恢复微血管灌注以改善氧合、预防组织缺氧和维持器官功能是血流动力学复苏的主要目标。因此，微循环目标可能代表优化循环休克治疗的最重要终点。
