Department of Biostatistics, College of Public Health and Health Professions, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
Stat Med. 2013 Apr 15;32(8):1325-35. doi: 10.1002/sim.5625. Epub 2012 Sep 13.
In order to adjust individual-level covariate effects for confounding due to unmeasured neighborhood characteristics, we have recently developed conditional pseudolikelihood methods to estimate the parameters of a proportional odds model for clustered ordinal outcomes with complex survey data. The methods require sampling design joint probabilities for each within-neighborhood pair. In the present article, we develop a similar methodology for a baseline category logit model for clustered multinomial outcomes and for a loglinear model for clustered count outcomes. All of the estimators and asymptotic sampling distributions we present can be conveniently computed using standard logistic regression software for complex survey data, such as sas proc surveylogistic. We demonstrate validity of the methods theoretically and also empirically by using simulations. We apply the new method for clustered multinomial outcomes to data from the 2008 Florida Behavioral Risk Factor Surveillance System survey in order to investigate disparities in frequency of dental cleaning both unadjusted and adjusted for confounding by neighborhood.
为了调整由于未测量的邻里特征引起的混杂个体水平协变量效应,我们最近开发了条件拟似然方法,以便使用复杂调查数据估计具有聚类有序结局的比例优势模型的参数。该方法需要对每个邻里对的抽样设计联合概率进行估计。在本文中,我们为聚类多项结局的基线类别对数几率模型和聚类计数结局的对数线性模型开发了类似的方法。我们提出的所有估计量和渐近抽样分布都可以使用适用于复杂调查数据的标准逻辑回归软件(如 sas proc surveylogistic)方便地计算。我们通过理论和模拟经验验证了这些方法的有效性。我们将新的聚类多项结局方法应用于 2008 年佛罗里达州行为风险因素监测系统调查的数据,以调查未经邻里因素混杂调整和调整后的牙科清洁频率差异。