Ngendahayo Placide, Faverly Daniel, Hérin Michel
Institut de Pathologie et Génétique (IPG), Gosselies, Belgium.
Int J Surg Pathol. 2013 Apr;21(2):177-80. doi: 10.1177/1066896912457203. Epub 2012 Sep 12.
Primary breast amyloidosis is a rare disease and usually occurs as unilateral or bilateral palpable masses. Primary breast amyloidosis presenting solely as microcalcifications is extremely rare. The authors report a case of a 73-year-old woman with persistent suspicious microcalcifications without palpable mass. The diagnosis was established by the presence of an amorphous and eosinophilic material that was positive for Congo red and dichroic under polarized light. Paraffin immunohistochemistry revealed the presence of kappa light chains (AL-type amyloidosis). The amyloid deposits were associated with microcalcifications. A complete work up was performed to exclude other localisations or associated pathologies and was negative. The primary breast amyloidosis is discussed and a review of the literature is presented.
原发性乳腺淀粉样变性是一种罕见疾病，通常表现为单侧或双侧可触及的肿块。仅表现为微钙化的原发性乳腺淀粉样变性极为罕见。作者报告了一例73岁女性病例，该患者存在持续的可疑微钙化，但未触及肿块。通过存在一种无定形嗜酸性物质确诊，该物质刚果红染色阳性且在偏振光下呈双色性。石蜡免疫组化显示存在κ轻链（AL型淀粉样变性）。淀粉样沉积物与微钙化有关。进行了全面检查以排除其他部位或相关病理情况，结果均为阴性。本文讨论了原发性乳腺淀粉样变性并对文献进行了综述。
