De Crem Anne-Sofie, Van de Vijver Koen, De Visschere Pieter, Van den Broecke Rudy, Göker Menekse
UGent, BE.
Ghent University Hospital, BE.
J Belg Soc Radiol. 2022 Dec 19;106(1):134. doi: 10.5334/jbsr.2988. eCollection 2022.
Amyloidosis is an uncommon disorder characterized by extracellular accumulation of misfolded proteins in tissues. We report a unique case of localized breast amyloidosis in an asymptomatic 56-year-old woman with systemic lupus erythematosus, presented as suspicious microcalcifications without mass on mammography. Vacuum biopsy confirmed amyloidosis, producing the typical apple-green birefringence under polarized light after staining with Congo-red. Further workup and follow-up to exclude development into systemic amyloidosis or hematologic malignancy is recommended. If negative, the prognosis is very good, thus no further treatment is needed. A brief review of the literature revealed more about the typical findings and recommended management.
淀粉样变性是一种罕见的疾病，其特征是组织中错误折叠的蛋白质在细胞外积聚。我们报告了一例独特的局限性乳腺淀粉样变性病例，患者为一名56岁无症状的系统性红斑狼疮女性，乳腺X线摄影显示为可疑微钙化灶，无肿块。真空活检确诊为淀粉样变性，刚果红染色后在偏振光下产生典型的苹果绿双折射。建议进一步检查和随访以排除发展为系统性淀粉样变性或血液系统恶性肿瘤。如果结果为阴性，预后非常好，因此无需进一步治疗。对文献的简要回顾揭示了更多典型发现和推荐的管理方法。
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