Herberman R B
Ann Clin Lab Sci. 1979 Nov-Dec;9(6):467-73.
Cellular immune competence and cell-mediated immunity to tumor antigens have been studied in patients with breast cancer. Some patients have been shown to have depressed lymphoproliferative responses to phytohemagglutinin and in mixed leukocyte culture. In some cases, this depression appeared attributable to suppressor cells. Many patients with breast cancer had a cellular immunity to extracts of autologous or allogenetic tumors, as detected by lymphoproliferation and leukocyte migration inhibition assays. In addition, some breast cancer patients reacted to antigens associated with murine mammary tumor virus. Some of the tests for cellular immunity have revealed correlations with clinical course and, therefore, may be of use in the management of patients with breast cancer.
对乳腺癌患者的细胞免疫能力以及针对肿瘤抗原的细胞介导免疫进行了研究。一些患者对植物血凝素以及混合白细胞培养中的淋巴细胞增殖反应表现出抑制。在某些情况下，这种抑制似乎归因于抑制细胞。通过淋巴细胞增殖和白细胞迁移抑制试验检测发现，许多乳腺癌患者对自体或同种异体肿瘤提取物具有细胞免疫。此外，一些乳腺癌患者对与鼠乳腺肿瘤病毒相关的抗原产生反应。一些细胞免疫测试揭示了与临床病程的相关性，因此可能在乳腺癌患者的管理中有用。
