铱(NTf2)3 催化的色酮亚胺硝酮与环丙烷之间的[3 + 3]环加成反应，构建新型螺[四氢-1,2-恶嗪]氧吲哚。
Yb(NTf2)3-catalyzed [3 + 3] cycloaddition between isatin ketonitrones and cyclopropanes to construct novel spiro[tetrahydro-1,2-oxazine]oxindoles.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PR China.
出版信息
Org Biomol Chem. 2012 Oct 3;10(41):8236-43. doi: 10.1039/c2ob26413g.
PMID:22976783
Abstract
Yb(NTf(2))(3)-catalyzed [3 + 3] cycloaddition between isatin ketonitrones and cyclopropanes is described. A variety of spiro[tetrahydro-1,2-oxazine]oxindoles were obtained in moderate to good yields along with good regioselectivities. This is the first example of the intermolecular [3 + 3] cycloaddition between ketone-derived nitrones and cyclopropanes.
摘要
铱(NTf(2))(3)催化的色酮亚胺硝酮与环丙烷的[3 + 3]环加成反应被描述。多种螺[四氢-1,2-恶嗪]氧吲哚以中等至良好的收率和良好的区域选择性得到。这是酮衍生的亚胺硝酮与环丙烷之间的首例分子间[3 + 3]环加成反应。
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