Faculty of Medicine, Division of Pediatrics, Department of Reproductive and Developmental Medicine, University of Miyazaki, Miyazaki, Japan.
Pediatr Blood Cancer. 2013 Feb;60(2):329-31. doi: 10.1002/pbc.24298. Epub 2012 Sep 13.
We describe a 5-year-old female with acute lymphoblastic leukemia (ALL) who suffered from cytomegalovirus (CMV) retinitis during maintenance therapy consisting of 6-mercaptopurine (6-MP) and methotrexate (MTX) with pulses of vincristine (VCR) and dexamethasone (DEX). Administration of anticytomegaloviral drugs led to a complete regression of active retinitis. Her low CD4 positive T cells and serum immunoglobulin G (IgG) recovered when maintenance therapy was resumed without VCR and DEX. The patient has been in complete remission (CR) for more than 5 months after completion of maintenance therapy without recurrence of CMV retinitis.
我们描述了一位 5 岁女性急性淋巴细胞白血病（ALL）患者，在包含巯嘌呤（6-MP）和甲氨蝶呤（MTX）以及长春新碱（VCR）和地塞米松（DEX）脉冲的维持治疗期间患有巨细胞病毒（CMV）视网膜炎。抗巨细胞病毒药物的使用导致活动性视网膜炎完全消退。当维持治疗恢复时，不使用 VCR 和 DEX，她的低 CD4 阳性 T 细胞和血清免疫球蛋白 G（IgG）恢复。完成维持治疗后，患者已超过 5 个月处于完全缓解（CR）状态，且 CMV 视网膜炎未再复发。
