吡啶-2-酮和吡啶-4-酮的金属有机钌和锇化合物作为潜在的抗癌剂。
Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents.
机构信息
University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, AT-1090 Vienna.
出版信息
Chem Biodivers. 2012 Sep;9(9):1718-27. doi: 10.1002/cbdv.201200005.
Organometallic Ru(II) compounds are among the most widely studied anticancer agents. Functionalizing metal centers with biomolecule-derived ligands has been shown to be a promising strategy to improve the antiproliferative activity of metal-based chemotherapeutics. Herein, the synthesis of a series of novel 3-hydroxypyridin-2-one-derived ligands and their M(II)(η(6)-p-cymene) half-sandwich complexes (M = Ru, Os) is described. The compounds were characterized by 1D- and 2D-NMR spectroscopy, and elemental analysis.
有机金属钌(II)化合物是研究最广泛的抗癌药物之一。用生物分子衍生的配体功能化金属中心已被证明是提高基于金属的化疗药物抗增殖活性的一种很有前途的策略。本文描述了一系列新型 3-羟基吡啶-2-酮衍生配体及其 M(II)(η(6)-p-枯烯)半夹心配合物（M = Ru，Os）的合成。通过 1D 和 2D-NMR 光谱以及元素分析对化合物进行了表征。
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