Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA.
J Clin Endocrinol Metab. 2012 Dec;97(12):4446-53. doi: 10.1210/jc.2012-2378. Epub 2012 Sep 13.
It is unclear whether there is a racial difference in the incidence of diabetic complications in underinsured populations.
The objective of the study was to investigate racial disparities in the incidence of diabetic complications within the Louisiana State University (LSU) Hospital System.
This study (1997-2009) was conducted on a diabetic cohort enrolled in the LSU Hospital-Based Longitudinal Study. The cohort included 16,808 non-Hispanic white men, 21,983 non-Hispanic white women, 20,621 African-American men, and 33,753 African-American women who were 30-96 yr of age and had a mean value of family income of $9641/yr at baseline.
The study cohort had a mean follow-up of 4.4 years. The age- and sex-adjusted incidence rates and 95% confidence intervals of end-stage renal disease (ESRD), coronary heart disease (CHD), heart failure (HF), and stroke for white diabetic patients were 15.1 (14.3-15.8), 80.9 (78.9-82.9), 48.0 (46.6-49.4), and 21.4 (20.5-22.2) per 1000 person-years, respectively. Compared with white diabetic patients, African-American diabetic patients experienced higher incident rates of ESRD [17.3 (16.6-18.0)] and lower rates of CHD [47.5 (46.3-48.6)], HF [40.7 (39.6-41.8)], and stroke [19.1 (18.4-19.9)]. Female diabetic patients had lower rates of the four complications than male diabetic patients. Results of the Cox proportional hazard models confirmed sex and race disparity observed in the age-adjusted incidence rates.
Despite equal access to care, diabetic African-Americans have a higher risk of ESRD than their white counterparts, whereas diabetic whites have higher risks of CHD, HF, and stroke than their African-American counterparts.
在保险覆盖不足的人群中,糖尿病并发症的发病率是否存在种族差异尚不清楚。
本研究旨在调查路易斯安那州立大学(LSU)医院系统内糖尿病并发症的发病率存在种族差异。
本研究(1997-2009 年)在 LSU 医院纵向研究中纳入的糖尿病队列中进行。该队列包括 16808 名非西班牙裔白人男性、21983 名非西班牙裔白人女性、20621 名非裔美国男性和 33753 名非裔美国女性,年龄 30-96 岁,基线时家庭平均收入为 9641 美元/年。
研究队列的平均随访时间为 4.4 年。白人糖尿病患者的终末期肾病(ESRD)、冠心病(CHD)、心力衰竭(HF)和中风的年龄和性别调整发病率及 95%置信区间分别为 15.1(14.3-15.8)、80.9(78.9-82.9)、48.0(46.6-49.4)和 21.4(20.5-22.2)/1000 人年。与白人糖尿病患者相比,非裔美国糖尿病患者 ESRD 的发病率更高[17.3(16.6-18.0)],CHD 的发病率更低[47.5(46.3-48.6)],HF 的发病率更低[40.7(39.6-41.8)],中风的发病率更低[19.1(18.4-19.9)]。女性糖尿病患者的这四种并发症发生率均低于男性糖尿病患者。Cox 比例风险模型的结果证实了年龄调整发病率中观察到的性别和种族差异。
尽管获得了平等的医疗保健机会,但非裔美国糖尿病患者的 ESRD 风险高于其白人患者,而白人糖尿病患者的 CHD、HF 和中风风险高于其非裔美国患者。