Sleep Clinic for Developmental Age, Clinic of Child and Adolescent Neuropsychiatry, Second University of Naples, Naples, Italy.
Neuropsychiatr Dis Treat. 2012;8:369-73. doi: 10.2147/NDT.S35974. Epub 2012 Aug 23.
The relationship between sleep and mood regulation is well known, and some reports suggest a key role of sleep-related breathing disorders (SRBD) in the development of the symptomatology of depression, even if no conclusive data are actually found in the clinical literature. The aim of this study was to assess the relationship between SRBD and depressive symptoms in a population of school-aged children.
The study population comprised 94 children affected by SRBD and 107 healthy children. To identify the severity of SRBD, an overnight respiratory evaluation was performed. All subjects filled out the Italian version of the Children Depression Inventory (CDI) to screen for the presence of depressive symptoms.
The group with SRBD showed higher CDI scores than the group without SRBD, with a positive correlation found between CDI scores, apnea-hypopnea index, and oxygen desaturation index values. Logistic regression showed that an apnea-hypopnea index ≥ 3 and an oxygen desaturation index ≥ 1 could be risk factors for development of depressive symptoms. According to receiver-operating characteristic curve analysis, the cutoff point for the apnea-hypopnea index that could cause a pathological CDI score (≥19) was >5.66, and the cutoff point for the oxygen desaturation index was >4.2. The limitations of this study are that our data are derived from one single psychometric test and not from a complete psychiatric evaluation, and our subjects came from a small group in southern Italy.
Our results suggest the importance of mood assessment in children affected by SRBD.
睡眠与情绪调节之间的关系是众所周知的，一些报告表明睡眠相关呼吸障碍（SRBD）在抑郁症症状的发展中起着关键作用，尽管在临床文献中实际上并没有找到确凿的数据。本研究的目的是评估 SRBD 与学龄儿童抑郁症状之间的关系。
研究人群包括 94 名患有 SRBD 的儿童和 107 名健康儿童。为了确定 SRBD 的严重程度，进行了一整夜的呼吸评估。所有受试者都填写了意大利语版的儿童抑郁量表（CDI），以筛查是否存在抑郁症状。
患有 SRBD 的组的 CDI 评分高于没有 SRBD 的组，并且 CDI 评分、呼吸暂停-低通气指数和氧减饱和指数值之间存在正相关。逻辑回归显示，呼吸暂停-低通气指数≥3 和氧减饱和指数≥1 可能是发展为抑郁症状的危险因素。根据受试者工作特征曲线分析，导致病理性 CDI 评分（≥19）的呼吸暂停-低通气指数的截断点为>5.66，氧减饱和指数的截断点为>4.2。本研究的局限性在于我们的数据来自单一的心理测试，而不是完整的精神病学评估，并且我们的受试者来自意大利南部的一个小群体。
我们的结果表明，在患有 SRBD 的儿童中进行情绪评估的重要性。
