用铟-111标记的抗肌球蛋白单克隆抗体复合物对横纹肌肉瘤和平滑肌肉瘤进行放射免疫检测。
Radioimmunodetection in rhabdo- and leiomyosarcoma with 111In-anti-myosin monoclonal antibody complex.
作者信息
Planting A, Verweij J, Cox P, Pillay M, Stoter G
机构信息
Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands.
出版信息
Cancer Res. 1990 Feb 1;50(3 Suppl):955s-957s.
In patients with rhabdo- and leiomyosarcoma a radioimmunodiagnostic study was performed with 111In labeled F(ab) fragments of a monoclonal antibody against myosin. Eight patients with rhabdomyosarcoma and 18 patients with leiomyosarcoma were studied. Scanning was performed at 4, 24, and 48 h after administration of 74 MBeq of the antibody complex. A high uptake with a tumor:background ratio of 10:1 was observed in several patients with rhabdomyosarcoma but the results were less accurate in leiomyosarcoma.
对横纹肌肉瘤和平滑肌肉瘤患者进行了放射免疫诊断研究，使用111铟标记的抗肌球蛋白单克隆抗体的F(ab)片段。研究了8例横纹肌肉瘤患者和18例平滑肌肉瘤患者。在注射74兆贝可的抗体复合物后4小时、24小时和48小时进行扫描。在几例横纹肌肉瘤患者中观察到高摄取，肿瘤与背景比值为10:1，但在平滑肌肉瘤中的结果准确性较低。
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