Ren Chuanli, Han Chongxu, Wang Daxin, Zhao Xiaohang, Jin Guangfu, Shen Hongbing
Clinical Laboratory, Medical College of Yangzhou University, Yangzhou;
Exp Ther Med. 2011 May;2(3):385-391. doi: 10.3892/etm.2011.234. Epub 2011 Mar 21.
Most cancer-related deaths are caused by the hematogenous spread of cancer cells to distant organs and their subsequent metastasis. During the early stages of the metastatic cascade, cancer cells disseminate from the primary site via the lymphatic vessels and/or by hematogenous routes. Circulating tumor cells (CTCs), cancer cells that have disseminated into the systemic circulation, may be a predictor of poor prognosis in several carcinomas. An understanding of the molecular mechanisms involved in the blood-borne dissemination of cancer cells may help to clarify the process of metastasis and provide a powerful and non-invasive approach for anticancer treatments that are tailored to individual patients.
大多数癌症相关死亡是由癌细胞通过血液扩散至远处器官并随后发生转移所致。在转移级联反应的早期阶段，癌细胞通过淋巴管和/或血行途径从原发部位播散。循环肿瘤细胞（CTC），即已播散进入体循环的癌细胞，可能是几种癌症预后不良的预测指标。了解癌细胞血行播散所涉及的分子机制，可能有助于阐明转移过程，并为针对个体患者的抗癌治疗提供一种有力且非侵入性的方法。
