Hong Zhenghua, Hong Huaxing, Chen Haixiao, Wang Zhangfu, Hong Dun
Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Taizhou 317000, P.R. China.
Exp Ther Med. 2011 Sep;2(5):837-841. doi: 10.3892/etm.2011.285. Epub 2011 Jun 14.
Erythropoietin (EPO) is a promising therapeutic agent used in a variety of spinal cord injuries. Therefore, identifying the specific molecular pathway mediating the neuronal protective effect of EPO after spinal cord injury (SCI) is of great value to the patients concerned. Platelet-derived growth factor (PDGF)-B is an important factor in the recovery of neurological function. We explored changes in the expression of PDGF-B in spinal cord injury rats after receiving EPO treatment. We used a weight-drop contusion SCI model, and EPO treatment group rats received single doses of EPO (1,000 U/kg i.p.) immediately after the operation. Seven days after the operation, the results revealed a more rapid recovery as noted by the higher BBB scores, less disruption and more neuronal regeneration of the spinal cord in the EPO treatment group than that in the SCI group. PDGF-B expression also increased in the EPO treatment group compared to that in the SCI group (P<0.01). This study showed that PDGF-B plays a role in the neuronal protective effect of EPO on spinal cord injury in rats, which may help to explain the quick recovery after EPO treatment of spinal cord injury.
促红细胞生成素（EPO）是一种用于多种脊髓损伤的有前景的治疗药物。因此，确定脊髓损伤（SCI）后介导EPO神经元保护作用的具体分子途径对相关患者具有重要价值。血小板衍生生长因子（PDGF）-B是神经功能恢复中的一个重要因素。我们探究了接受EPO治疗的脊髓损伤大鼠中PDGF-B表达的变化。我们采用重物坠落挫伤性SCI模型，EPO治疗组大鼠在术后立即接受单剂量EPO（1000 U/kg腹腔注射）。术后7天，结果显示，与SCI组相比，EPO治疗组的BBB评分更高，脊髓破坏更少，神经元再生更多，恢复更快。与SCI组相比，EPO治疗组中PDGF-B的表达也增加了（P<0.01）。本研究表明，PDGF-B在EPO对大鼠脊髓损伤的神经元保护作用中发挥作用，这可能有助于解释EPO治疗脊髓损伤后恢复较快的原因。
