Makhnovskiy D A, Murzina G B, Pivovarov A S
Department of Higher Nervous Activity, M. V. Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2012 Aug;153(4):424-7. doi: 10.1007/s10517-012-1731-7.
Exocytosis inhibitor Exo 1 potentiates depression of acetylcholine-induced inward current in defensive behavior command neurons of edible snail, when acetylcholine is applied rhythmically to the soma in cellular correlate of habituation. A mathematical model presupposing different receptor localization in the cell and regularities of their translocations made it possible to analyze the dependence of acetylcholine-induced current depression on a number of intracellular processes. It was concluded that depression of choline-sensitive extrasynaptic zones on the membrane of defensive behavior command neurons in edible snail in cellular correlate of habituation is partially determined by attenuation of exocytosis of internalized cholinergic receptors.
胞吐作用抑制剂Exo 1增强了可食用蜗牛防御行为指令神经元中乙酰胆碱诱导的内向电流的抑制作用，当在习惯化的细胞关联中以节律性方式将乙酰胆碱施加到细胞体时。一个假设细胞中不同受体定位及其转运规律的数学模型使得分析乙酰胆碱诱导的电流抑制对许多细胞内过程的依赖性成为可能。得出的结论是，在可食用蜗牛防御行为指令神经元膜上胆碱敏感的突触外区域在习惯化的细胞关联中的抑制作用部分由内化胆碱能受体的胞吐作用减弱所决定。
