Acosta-Torres Sara M, Torres-Espina Marco T, Colina-Araujo José A, Colina-Chourio José A
Departamento de Pediatría, Hospital Materno-Infantil "Dr. Raúl Leoni", Escuela de Medicina, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Invest Clin. 2012 Jun;53(2):148-56.
The objective of the present study was to correlate seric values of bilirubin with the Kramer's index in a group of newborns with neonatal jaundice, from three different ethnic groups. This was a prospective, randomized, observational, descriptive-analytical, longitudinal, comparative and controlled study of 50 newborns with neonatal jaundice, without complications. They were divided into three groups: A (Control), n = 25, of Caucasian descent; B, n = 15, of local indigenous descent (Wayúu) and C, n = 10, of Afro-American descent. Each newborn was screened at the start of the study for their Kramer's dermic areas and simultaneously, a venous blood sample from the arm was taken for bilirubin quantification. They were compared through a correlation-regression analysis. Values at the beginning of the study were: serum bilirubin 12.02 +/- 3.41 mg/dL, and 62.8% of neonates were at Kramer's level 3. There were no differences among the ethnic groups studied and the correlation bilirubin/Kramer's index was r= 0.93 (p < 0.005). At the third day, both bilirubin and Kramer's indexes started to decrease. There were no ethnic differences. In conclusion, the Kramer's method offers multiple advantages to evaluate a jaundiced newborn; it is a safe, non-invasive method with no cost. Besides, it is of great help in the prevention of the kernicterus. It is recommended to implement the use of the Kramer method in all the newborns units in our Hospitals, preferably in those lacking transcutaneous bilirubinometers.
本研究的目的是在一组患有新生儿黄疸的来自三个不同种族的新生儿中,将血清胆红素值与克莱默指数进行关联分析。这是一项针对50例无并发症的新生儿黄疸患儿的前瞻性、随机、观察性、描述性分析、纵向、比较性和对照研究。他们被分为三组:A组(对照组),n = 25,为白种人后裔;B组,n = 15,为当地原住民(瓦尤族)后裔;C组,n = 10,为非裔美国人后裔。在研究开始时,对每个新生儿进行克莱默皮肤面积筛查,同时,从手臂采集静脉血样本进行胆红素定量分析。通过相关性回归分析对它们进行比较。研究开始时的值为:血清胆红素12.02 +/- 3.41 mg/dL,62.8%的新生儿处于克莱默3级水平。所研究的种族之间没有差异,胆红素/克莱默指数的相关性为r = 0.93(p < 0.005)。在第三天,胆红素和克莱默指数均开始下降。没有种族差异。总之,克莱默方法在评估黄疸新生儿方面具有多种优势;它是一种安全、无创且无成本的方法。此外,它对预防核黄疸有很大帮助。建议在我们医院的所有新生儿病房实施克莱默方法的使用,尤其是在那些没有经皮胆红素测定仪的病房。