在双相情感障碍患者急性躁狂期间，加巴喷丁辅助治疗。
Adjunctive treatment with gabapentin in bipolar patients during acute mania.
机构信息
University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
出版信息
Int J Psychiatry Med. 2012;43(3):261-71. doi: 10.2190/PM.43.3.e.
OBJECTIVE
In this clinical trial, we studied the effects of adjunctive treatment with gabapentin in controlling the symptoms of acute mania in patients admitted with bipolar disorder.
METHOD
Sixty patients with bipolar disorder (30 men and 30 women) admitted in the acute phase of mania were categorized as case and control groups, each holding 30 patients. Both groups were treated with lithium for 6 weeks and the case group received an adjunctive treatment with 900 mg gabapentin simultaneously. All patients were evaluated at the beginning and the end of the trial using Young's Mania Rating Scale (YMRS), and two groups were compared for improvement in acute symptoms.
FINDINGS
The final score of YMRS was significantly improved in the case group compared to the control group (p = 0.00). The improvement of YMRS score was not significantly different between men and women and between different age groups.
CONCLUSION
Adjunctive treatment with gabapentin is effective for controlling symptoms of acute mania.
目的
本临床试验旨在研究加巴喷丁辅助治疗对双相情感障碍患者急性躁狂症状的控制效果。
方法
将 60 名双相情感障碍（男 30 名，女 30 名）急性躁狂期入院患者分为病例组和对照组，各 30 名。两组均给予锂盐治疗 6 周，病例组同时给予加巴喷丁 900mg 辅助治疗。采用 Young 躁狂量表（YMRS）在试验开始和结束时对所有患者进行评估，并比较两组急性症状的改善情况。
结果
与对照组相比，病例组 YMRS 评分的终末评分显著改善（p=0.00）。YMRS 评分的改善在男性和女性之间以及不同年龄组之间无显著差异。
结论
加巴喷丁辅助治疗对控制急性躁狂症状有效。
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