Huang Jun, Qiu Chao, Zhang Xiao-Yan
Shanghai Public Health Clinical Center Affiliated to Fudan University, Institutes of Biomedical Sciences, Fudan University, Shanghai 201508, China.
Bing Du Xue Bao. 2012 Jun;28(4):477-81.
The SAM and HD domain containing protein 1 (Sterile alpha motif domain and HD domain-containing protein 1, SAMHD1) is a putative negative regulator of the antiviral innate immune response. It can significantly increase the antiviral immune response, mediates the interferon-induced inflammatory response involved in the host foreign-virus defense system. The early studies have focused on its gene mutations associated with Aicardi-Goutières syndrome (AGS), the latest study found that SAMHD1 as a potent dGTP-stimulated triphosphohydrolase restricts HIV-1 replication by hydrolyzing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis. Auxiliary gene of HIV-2 and simian immunodeficiency virus (SIVsm / mac) encoding the Vpx protein can eliminate HIV-1 restriction. In recent years, the research on SAMHD1, mores forward rapidly this paper overviews the recent research progression related to the above fields.
含SAM和HD结构域蛋白1（无菌α基序结构域和含HD结构域蛋白1，SAMHD1）是抗病毒天然免疫反应的一种假定负调节因子。它能显著增强抗病毒免疫反应，介导参与宿主对外来病毒防御系统的干扰素诱导的炎症反应。早期研究集中在其与Aicardi-Goutières综合征（AGS）相关的基因突变上，最新研究发现，SAMHD1作为一种有效的dGTP刺激三磷酸水解酶，通过水解大多数细胞dNTP来限制HIV-1复制，从而抑制逆转录和病毒互补DNA（cDNA）合成。HIV-2和猿猴免疫缺陷病毒（SIVsm/mac）的辅助基因编码的Vpx蛋白可消除HIV-1限制。近年来，关于SAMHD1的研究进展迅速，本文综述了上述领域的最新研究进展。
