Prieto J J, Rueda J, Merchan J A
Department of Histology, Faculty of Medicine, University of Alicante, Spain.
Brain Res Dev Brain Res. 1990 Jan 1;51(1):138-41. doi: 10.1016/0165-3806(90)90268-4.
The density of glycogen particles in organ of Corti's sensory cells was measured to determine the effect of congenital hypothyroidism upon the normal development of this energy source. This density in both normal and hypothyroid inner hair cells remains in low values from birth to adulthood. On the other hand, that of normal outer hair cells undergoes a great increase between the 10th and the 20th postnatal days, coinciding with the maturation of both the efferent innervation of these cells and the tuning properties of the auditory receptor. The glycogen stores of the hypothyroid outer hair cells do not show any significant increase from birth to adulthood. This latter fact suggests that the congenital hypothyroidism restrains the development of an important energy source of outer hair cells, most surely disturbing the physiological processes relying on glycogen metabolism.
测量柯蒂氏器官感觉细胞中糖原颗粒的密度，以确定先天性甲状腺功能减退对这种能量来源正常发育的影响。正常和甲状腺功能减退的内毛细胞中的这种密度从出生到成年都保持在较低水平。另一方面，正常外毛细胞的密度在出生后第10天到第20天之间大幅增加，这与这些细胞的传出神经支配和听觉感受器的调谐特性的成熟相吻合。甲状腺功能减退的外毛细胞的糖原储备从出生到成年没有显示出任何显著增加。后一事实表明，先天性甲状腺功能减退抑制了外毛细胞重要能量来源的发育，很可能干扰了依赖糖原代谢的生理过程。
