Farahpour M R, Sharifi D, B A A, Veshkini A, Soheil A
Department of Clinical Science, Islamic Azad University, Uromia, Iran.
Bratisl Lek Listy. 2012;113(9):529-33. doi: 10.4149/bll_2012_119.
The objective of this study is to radiologically evaluate the effects of biphasic calcium phosphate scaffold with 5, 10 and 20 percentage of porosity on cortical bone repair in rabbits. In this study, 28 male white rabbits were examined. Rabbits were divided into four groups. After induction of general anesthesia, a segmental bone defect of 10 mm in length was created in the middle of the right radius shaft. In group A, the defect was stabilized with miniplate and 2 screws and left untreated. In groups B, C and D tricalcium phosphate scaffold mixed with hydroxyapatite (TCP+HA) with 5%, 10% and 20% porosity was used to fi ll the bone defect. Bone regeneration and HA+TCP scaffold resorption were assessed by X-ray at 1, 2 and 3 months after the surgery. In group A, 3 months after surgery, periosteal callus was not found but intercortical callus was observed. In groups B and C, 3 months after surgery medullary bridging callus and intercortical callus were found, periosteal callus was not found, TCP+HA scaffold were observed. In group D, 2 months after the surgery, medullary bridging callus and intercortical callus were found, 3 months later, periosteal callus was not found, most of scaffold had disappeared and were unclear and partial bone formation was recognized. Differences observed in radiological findings were significant between group A and groups B, C, D. Differences between groups B and C were not significant, but between group D and groups B and C were significant. The results of this study showed that TCP+HA scaffold is an osteoconductive and osteoinductive biomaterial. Scaffold of TCP+HA can increase the amount of newly formed bone and more rapid regeneration of bone defects. These results suggest TCP+HA scaffold may considerably be used in the treatment of cortical bone defect and other orthopaedic defects PCL (Tab. 2, Fig. 4, Ref. 20).
本研究的目的是通过放射学方法评估孔隙率分别为5%、10%和20%的双相磷酸钙支架对兔皮质骨修复的影响。在本研究中，对28只雄性白兔进行了检查。将兔子分为四组。全身麻醉诱导后，在右桡骨干中部制造一个10毫米长的节段性骨缺损。A组中，缺损用微型钢板和2枚螺钉固定，未进行其他处理。B、C和D组使用孔隙率分别为5%、10%和20%的磷酸三钙支架与羟基磷灰石混合（TCP+HA）填充骨缺损。术后1、2和3个月通过X射线评估骨再生和HA+TCP支架吸收情况。A组术后3个月未发现骨膜骨痂，但观察到皮质间骨痂。B组和C组术后3个月发现髓内桥接骨痂和皮质间骨痂，未发现骨膜骨痂，观察到TCP+HA支架。D组术后2个月发现髓内桥接骨痂和皮质间骨痂，3个月后未发现骨膜骨痂，大部分支架已消失且不清晰，可见部分骨形成。A组与B、C、D组在放射学检查结果上观察到的差异具有显著性。B组和C组之间的差异不显著，但D组与B组和C组之间的差异具有显著性。本研究结果表明，TCP+HA支架是一种具有骨传导性和骨诱导性的生物材料。TCP+HA支架可增加新形成骨的量，并使骨缺损更快再生。这些结果表明，TCP+HA支架可大量用于治疗皮质骨缺损和其他骨科缺损PCL（表2，图4，参考文献20）。
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