University Center of Legal Medicine, Geneva-Lausanne, Rue Michel-Servet 1, 1211 Geneva, Rue de Bugnon 21, 1011 Lausanne, Switzerland.
Forensic Sci Int. 2012 Nov 30;223(1-3):e10-2. doi: 10.1016/j.forsciint.2012.08.019. Epub 2012 Sep 11.
Here we report the case of a 70-year-old woman who committed suicide by cyanide poisoning. During resuscitation cares, she underwent an antidote treatment by hydroxocobalamin. Postmortem investigations showed marked bright pink discolouration of organs and fluids, and a lethal cyanide blood concentration of 43 mg/L was detected by toxicological investigation. Discolouration of hypostasis and organs has widely been studied in forensic literature. In our case, we interpreted the unusual pink coloration as the result of the presence of hydroxocobalamin. This substance is a known antidote against cyanide poisoning, indicated because of its efficiency and poor adverse effects. However, its main drawback is to interfere with measurements of many routine biochemical parameters. We have tested the potential influence of this molecule in some routine postmortem investigations. The results are discussed.
这里我们报告了一例 70 岁女性因氰化物中毒自杀的案例。在复苏过程中，她接受了羟钴胺解毒治疗。尸检调查显示器官和体液呈现明显的亮粉红色变色，毒物学调查检测到血液中氰化物浓度为 43mg/L，达到致死量。尸僵和器官变色在法医学文献中有广泛研究。在我们的案例中，我们将异常的粉红色解释为羟钴胺的存在所致。该物质是氰化物中毒的已知解毒剂，因其有效且不良反应少而被推荐。然而，其主要缺点是会干扰许多常规生化参数的测量。我们已经测试了该分子对一些常规死后检查的潜在影响。结果进行了讨论。
