Charles Luenda E, Fekedulegn Desta, Miller Diane B, Wactawski-Wende Jean, Violanti John M, Andrew Michael E, Burchfiel Cecil M
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
Glob J Health Sci. 2012 Apr 28;4(3):39-50. doi: 10.5539/gjhs.v4n3p39.
The purpose of this study was to examine the association between depressive symptoms and bone mineral density (BMD).
Depressive symptoms were measured using the Center for Epidemiologic Studies Depression (CES-D) scale. BMD of total hip, femoral neck, anterio-posterior (AP) spine, wrist, and total body were measured by DXA using standardized procedures. Mean levels of BMD across gender-specific tertiles of CES-D score were obtained using ANOVA and ANCOVA.
Participants included 97 police officers (41 women; 29-64 years). Depressive symptoms were not associated with BMD at any site among men. However among women, mean BMD values decreased across increasing (worsening) tertiles of CES-D for the AP spine (low CES-D=1.22 ± 0.04; medium CES-D=1.05±0.04; high CES-D=1.03±0.04 g/cm2; p=0.035) and for the whole body (low=1.26±0.03; medium=1.20±0.03; high=1.11±0.03 g/cm2; p=0.018) after adjustment.
Higher depressive symptoms were associated with lower BMD among female but not male officers.
本研究旨在探讨抑郁症状与骨密度（BMD）之间的关联。
使用流行病学研究中心抑郁量表（CES-D）来测量抑郁症状。采用标准化程序通过双能X线吸收法（DXA）测量全髋、股骨颈、腰椎前后位、腕部和全身的骨密度。使用方差分析（ANOVA）和协方差分析（ANCOVA）获得CES-D评分按性别分层的三分位数分组中的骨密度平均水平。
研究对象包括97名警察（41名女性；年龄29 - 64岁）。男性中，抑郁症状与任何部位的骨密度均无关联。然而在女性中，调整后，腰椎前后位（低CES-D组 = 1.22 ± 0.04；中CES-D组 = 1.05 ± 0.04；高CES-D组 = 1.03 ± 0.04 g/cm²；p = 0.035）和全身（低 = 1.26 ± 0.03；中 = 1.20 ± 0.03；高 = 1.11 ± 0.03 g/cm²；p = 0.018）的骨密度均值随着CES-D评分三分位数的增加（抑郁症状加重）而降低。
女性警察中，较高的抑郁症状与较低的骨密度相关，而男性警察中则无此关联。
