基质辅助激光解析电离飞行时间/飞行时间质谱法在兴奋剂控制中的定性筛选：证据验证。

Qualitative screening in doping control by MALDI-TOF/TOF mass spectrometry: a proof-of-evidence.

机构信息

Department of Organic Chemistry and Biochemistry, University of Naples Federico II, Naples, Italy.

出版信息

J Pharm Biomed Anal. 2012 Dec;71:193-7. doi: 10.1016/j.jpba.2012.08.003. Epub 2012 Aug 27.

DOI:10.1016/j.jpba.2012.08.003

Abstract

The analysis of doping agents in biological fluids is of top significance in clinical and forensic toxicology. Herein we describe the study of a screening method for the detection of a mixture of drugs of potential abuse including cocaine and its metabolites. By using matrix-assisted laser desorption/ionization MALDI-TOF/TOF mass spectrometry. This screening procedure to detect the presence of different drugs, avoiding time consuming procedures could be useful in different fields of forensic analytical toxicology, including antidoping analysis.

摘要

在临床毒理学和法医毒理学中，对生物体液中的兴奋剂进行分析具有非常重要的意义。本文描述了一种用于检测潜在滥用药物混合物的筛选方法的研究，包括可卡因及其代谢物。通过使用基质辅助激光解吸/电离 MALDI-TOF/TOF 质谱法。这种筛选程序可以用于检测不同药物的存在，避免耗时的程序，可用于法医分析毒理学的不同领域，包括反兴奋剂分析。