Charité-Universitätsmedizin Berlin, Department of Anesthesiology, CCM, Charitéplatz 1, 10117 Berlin, Germany.
Vet J. 2013 Mar;195(3):377-81. doi: 10.1016/j.tvjl.2012.07.011. Epub 2012 Sep 12.
Movement responses to noxious stimuli during anaesthesia indicate nociception. Under experimental conditions consistent prediction of such movement responses has been achieved by the use of nociceptive flexion reflexes (NFRs). The aim of this study was to investigate the reliability of NFRs and the electroencephalogram bispectral index (BIS) in predicting motor responses to real surgical stimuli in pigs. The study was undertaken in 30 pigs undergoing bilateral orchiectomy under ketamine/azaperone anaesthesia. During the operation, movement responses to seven distinct surgical steps that provided noxious stimuli of different intensity were evaluated. Any movement response of limbs or the head was considered as a positive response. For each surgical step the values of NFRs and the BIS obtained just prior to the step were tested as predictors of movement responses. The prediction probability for movement responses was 0.58±0.04 for the BIS and 0.76±0.03 for the NFRs. It was concluded that NFRs but not the BIS can predict the effectiveness of ketamine anaesthesia in terms of the suppression of movement responses to surgical stimuli.
麻醉状态下对有害刺激的运动反应表明存在伤害感受。在实验条件下，通过使用伤害性屈肌反射（NFR）可以一致地预测这种运动反应。本研究旨在探讨 NFR 和脑电双频指数（BIS）在预测猪接受真实手术刺激时运动反应的可靠性。该研究在 30 头接受氯胺酮/安定麻醉下双侧去势手术的猪中进行。在手术过程中，评估了对七个不同强度的有害刺激的七种不同手术步骤的运动反应。任何四肢或头部的运动反应都被视为阳性反应。对于每个手术步骤，在该步骤之前获得的 NFR 和 BIS 值被测试为运动反应的预测因子。BIS 的运动反应预测概率为 0.58±0.04，而 NFR 的运动反应预测概率为 0.76±0.03。研究结论认为，NFR 但不是 BIS 可以预测氯胺酮麻醉在抑制手术刺激引起的运动反应方面的效果。
