Otulana B A, Higenbottam T, Ferrari L, Scott J, Igboaka G, Wallwork J
Department of Respiratory Physiology, Papworth Hospital, Cambridge, England.
Chest. 1990 Feb;97(2):353-7. doi: 10.1378/chest.97.2.353.
The value of home spirometry in detecting acute lung rejection and opportunistic infections was studied in 15 heart-lung transplant recipients over a six-month period. The patients measured their FEV1 and FVC twice daily at home using a portable turbine spirometer. The records were then reviewed in relation to the results of transbronchial lung biopsy carried out during occurrences of respiratory symptoms and during routine posttransplant assessment. FEV1 and FVC fell by a mean (+/- SD) of 10.4 +/- 6.9 percent and 9.3 +/- 7.9 percent, respectively, during 20 episodes of lung rejection. The corresponding figures during opportunistic infections were 12.8 +/- 10.1 percent and 12.5 +/- 14.3 percent. No such change was observed during routine normal biopsies. Regular home spirometry offered early detection of these complications allowing early transbronchial lung biopsy as well as assessing efficacy of their therapy. Above all, measurements can be made daily, which is unique in the assessment of solid organ transplants.
在六个月的时间里，对15名心肺移植受者进行了家庭肺量计检测急性肺排斥反应和机会性感染价值的研究。患者在家中使用便携式涡轮肺量计每天测量两次第一秒用力呼气容积（FEV1）和用力肺活量（FVC）。然后根据在出现呼吸道症状期间以及移植后常规评估期间进行的经支气管肺活检结果对记录进行审查。在20次肺排斥反应发作期间，FEV1和FVC平均（±标准差）分别下降了10.4±6.9%和9.3±7.9%。在机会性感染期间，相应的数字分别为12.8±10.1%和12.5±14.3%。在常规正常活检期间未观察到此类变化。定期家庭肺量计检测能够早期发现这些并发症，从而可以早期进行经支气管肺活检并评估治疗效果。最重要的是，可以每天进行测量，这在实体器官移植评估中是独一无二的。
