Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Taiwan, ROC.
Food Chem. 2012 Dec 15;135(4):2904-9. doi: 10.1016/j.foodchem.2012.07.073. Epub 2012 Jul 20.
The fruits of Persea americana (Avocado) are nowadays used as healthy fruits in the world. Bioassay-guided fractionation of the active ethyl acetate soluble fraction has led to the isolation of five new fatty alcohol derivatives, avocadenols A-D (1-4) and avocadoin (5) from the unripe pulp of P. americana, along with 12 known compounds (6-17). These structures were elucidated by spectroscopic analysis. Among the isolates, avocadenol A (1), avocadenol B (2), (2R,4R)-1,2,4-trihydroxynonadecane (6), and (2R,4R)-1,2,4-trihydroxyheptadec-16-ene (7) showed antimycobacterial activity against Mycobacterium tuberculosis H(37)R(V)in vitro, with MIC values of 24.0, 33.8, 24.9, and 35.7 μg/ml, respectively.
如今，鳄梨（Persea americana）的果实被视为健康水果在世界范围内得到应用。生物活性导向分离法对活性乙酸乙酯可溶部分进行分离，从而从鳄梨的未成熟果肉中分离得到五个新的脂肪酸醇衍生物，即鳄梨醇 A-D（1-4）和鳄梨醇（5），此外还有 12 种已知化合物（6-17）。这些结构通过光谱分析得到阐明。在所分离的化合物中，鳄梨醇 A（1）、鳄梨醇 B（2）、（2R,4R）-1,2,4-三羟基-1-十九烷醇（6）和（2R,4R）-1,2,4-三羟基-1-十七碳-16-烯（7）表现出针对结核分枝杆菌 H(37)R(V)的体外抗分枝杆菌活性，MIC 值分别为 24.0、33.8、24.9 和 35.7μg/ml。
Zotero 插件