美洲蒲桃未成熟果肉中的次生代谢产物及其抗分枝杆菌活性。
Secondary metabolites from the unripe pulp of Persea americana and their antimycobacterial activities.
机构信息
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Taiwan, ROC.
出版信息
Food Chem. 2012 Dec 15;135(4):2904-9. doi: 10.1016/j.foodchem.2012.07.073. Epub 2012 Jul 20.
The fruits of Persea americana (Avocado) are nowadays used as healthy fruits in the world. Bioassay-guided fractionation of the active ethyl acetate soluble fraction has led to the isolation of five new fatty alcohol derivatives, avocadenols A-D (1-4) and avocadoin (5) from the unripe pulp of P. americana, along with 12 known compounds (6-17). These structures were elucidated by spectroscopic analysis. Among the isolates, avocadenol A (1), avocadenol B (2), (2R,4R)-1,2,4-trihydroxynonadecane (6), and (2R,4R)-1,2,4-trihydroxyheptadec-16-ene (7) showed antimycobacterial activity against Mycobacterium tuberculosis H(37)R(V)in vitro, with MIC values of 24.0, 33.8, 24.9, and 35.7 μg/ml, respectively.
如今，鳄梨（Persea americana）的果实被视为健康水果在世界范围内得到应用。生物活性导向分离法对活性乙酸乙酯可溶部分进行分离，从而从鳄梨的未成熟果肉中分离得到五个新的脂肪酸醇衍生物，即鳄梨醇 A-D（1-4）和鳄梨醇（5），此外还有 12 种已知化合物（6-17）。这些结构通过光谱分析得到阐明。在所分离的化合物中，鳄梨醇 A（1）、鳄梨醇 B（2）、（2R,4R）-1,2,4-三羟基-1-十九烷醇（6）和（2R,4R）-1,2,4-三羟基-1-十七碳-16-烯（7）表现出针对结核分枝杆菌 H(37)R(V)的体外抗分枝杆菌活性，MIC 值分别为 24.0、33.8、24.9 和 35.7μg/ml。
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