Park SeonJu, Jeong Seo Yule, Nam Youn Hee, Park Jun Hyung, Rodriguez Isabel, Shim Ji Heon, Yasmin Tamanna, Kwak Hee Jae, Oh Youngse, Oh Mira, Lee Kye Wan, Lee Jung Suk, Kim Do Hoon, Park Yu Hwa, Moon In Seok, Choung Se-Young, Jeong Kwang Won, Hong Bin Na, Kim Seung Hyun, Kang Tong Ho
Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea.
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea.
Plants (Basel). 2021 Jan 18;10(1):171. doi: 10.3390/plants10010171.
Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2,4,6)-1,2,4-trihydroxynonadec-6-ene and (2,4)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.
鳄梨油对人体健康有益，据报道对感音神经性听力损失（SNHL）有有益作用。然而，鳄梨油中影响SNHL的化合物尚未被鉴定出来。在本研究中，我们通过广泛的光谱分析从鳄梨油中鉴定出20种化合物，包括两种新的和18种已知的脂肪酸衍生物。在耳毒性斑马鱼模型中研究了分离出的化合物改善SNHL的功效。两种新化合物，即(2,4,6)-1,2,4-三羟基十九碳-6-烯和(2,4)-1,2,4-三羟基十七碳-14,16-二烯（化合物1和2），以及化合物7、9、14、17和19在有毒斑马鱼中受损的毛细胞方面显示出显著改善。这些结果得出结论，鳄梨油中的化合物以及油本身对耳毒性斑马鱼中受损的耳毛细胞具有再生作用。
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