具有临床意义的抗M抗体——两例报告
Clinically significant anti M antibodies--a report of two cases.
作者信息
Kaur Gagandeep, Basu Sabita, Kaur Paramjit, Kaur Ravneet
机构信息
Department of Transfusion Medicine, Government Medical College and Hospital, Sector-32, Chandigarh 160032, India.
出版信息
Transfus Apher Sci. 2012 Dec;47(3):259-61. doi: 10.1016/j.transci.2012.07.023. Epub 2012 Sep 13.
INTRODUCTION
Most anti-M antibodies are not active at 37°C and are thus of no clinical significance. Occasionally these antibodies have a wide thermal range and can lead to hemolytic transfusion reactions or hemolytic disease of the new born.
PATIENT AND METHODS
We describe two cases of anti-M antibodies, both of which were clinically significant.
RESULTS
The first case was detected due to crossmatch incompatibility and the second presented as a blood group discrepancy.
CONCLUSION
When the antibody is active at 37°C, M antigen negative red cell units should be issued.
引言
大多数抗-M抗体在37°C时无活性，因此无临床意义。偶尔这些抗体具有较宽的热反应范围，可导致溶血性输血反应或新生儿溶血病。
患者与方法
我们描述了两例抗-M抗体病例，两例均具有临床意义。
结果
第一例因交叉配血不相合而被检测到，第二例表现为血型不符。
结论
当抗体在37°C时有活性时，应发放M抗原阴性的红细胞单位。
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