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[急性冠状动脉综合征患者心肾综合征的预后]

[Prognosis of cardiorenal syndrome in patients with acute coronary syndrome].

作者信息

Cabrerizo-García José Luis, Zalba-Etayo Begoña, Pérez-Calvo Juan Ignacio

机构信息

Servicio de Medicina Interna, Hospital General de la Defensa, Zaragoza, España.

出版信息

Med Clin (Barc). 2012 Oct 20;139(10):437-40. doi: 10.1016/j.medcli.2012.03.035. Epub 2012 Sep 12.

Abstract

BACKGROUND AND OBJECTIVE

The cardiorenal syndrome (CRS) includes numerous pathologies affecting the heart and kidney. The objective of this study is to know the characteristics and prognosis of the CRS in patients with acute coronary syndrome (ACS).

PATIENTS AND METHOD

A prospective study of 87 patients with ACS with and without ST-segment elevation at high risk and heart failure. We analysed the presence of CRS and its relationship with epidemiological variables, clinical, analytical and complementary explorations. Through a Cox regression model we investigated its relationship with mortality in the subsequent 6 months of the event.

RESULTS

Patients with CRS (43.7%) were more frequently women, older, with more prior cardiovascular disease and a profile of higher risk. The prognosis was significantly worse in this group and the CRS was an independent predictor of mortality (hazard ratio 3.08; 95% confidence interval 1.13-8,40; P=.029).

CONCLUSIONS

The presence of CRS has an influence in the prognosis of patients who suffer an ACS high-risk and increases the likelihood of dying during 6 months after the event.

摘要

背景与目的

心肾综合征(CRS)包括多种影响心脏和肾脏的病理状况。本研究的目的是了解急性冠状动脉综合征(ACS)患者中CRS的特征和预后。

患者与方法

一项对87例高危且伴有或不伴有ST段抬高的ACS及心力衰竭患者的前瞻性研究。我们分析了CRS的存在情况及其与流行病学变量、临床、分析和辅助检查的关系。通过Cox回归模型,我们研究了其与事件发生后6个月内死亡率的关系。

结果

CRS患者(43.7%)女性更常见,年龄更大,既往有更多心血管疾病,且风险更高。该组患者的预后明显更差,CRS是死亡率的独立预测因素(风险比3.08;95%置信区间1.13 - 8.40;P = 0.029)。

结论

CRS的存在对高危ACS患者的预后有影响,并增加了事件发生后6个月内死亡的可能性。

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