Kudriavets Iu I
Eksp Onkol. 1990;12(1):43-7.
Cells of the Lewis lung carcinoma (3LL), B16 melanoma and Ehrlich carcinoma pre-treated in vitro by a recombinant tumour necrosis factor (rTNF) were studied for their spontaneous and experimental metastatic spreading. The rTNF (1000 u/ml) was determined to stimulate a metastatic potential of the Lewis carcinoma cells after their treatment with the factor for 6 h and, vice versa, to inhibit it after 96 h prolonged treatment. The efficacy of the stimulating effect of rTNF on a metastatic spreading depends on the peculiarities of the studied cells.
对经重组肿瘤坏死因子（rTNF）体外预处理的Lewis肺癌（3LL）、B16黑色素瘤和艾氏癌的细胞进行了自发转移和实验性转移扩散的研究。已确定rTNF（1000单位/毫升）在用该因子处理Lewis癌细胞6小时后可刺激其转移潜能，反之，在延长处理96小时后则抑制其转移潜能。rTNF对转移扩散的刺激作用效果取决于所研究细胞的特性。
