分析可见-近红外光谱变化，以测量甲型和乙型流感病毒感染患者鼻黏膜区域的炎症反应。
Analysis of Vis-NIR spectra changes to measure the inflammatory response in the nasal mucosal region of influenza A and B virus-infected patients.
机构信息
Department of Virology, Center for Infectious Disease Control, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.
出版信息
J Clin Virol. 2012 Dec;55(4):334-8. doi: 10.1016/j.jcv.2012.08.015. Epub 2012 Sep 12.
BACKGROUND
Human influenza A and B viruses cause severe seasonal respiratory tract infections, especially in infants and young children. Influenza A and B viruses have been reported to produce different symptoms and/or severity in infected patients, although these remain inconclusive.
OBJECTIVES AND STUDY DESIGN
In this study, non-invasive visible and near-infrared (Vis-NIR) spectroscopy was used for comparative analysis of the inflammatory response to influenza A and B virus infections, by measuring changes in water peak (970 nm) spectra collected from patient nasal mucosal regions.
RESULTS
The results suggested that infection with influenza B virus induced more severe inflammatory responses in the nasal mucosal region than influenza A virus.
CONCLUSIONS
These are the first data showing different inflammatory responses to influenza A and B viruses at the sites of virus infection.
背景
甲型和乙型流感病毒会引起严重的季节性呼吸道感染，尤其是在婴幼儿中。据报道，甲型和乙型流感病毒在感染患者中会产生不同的症状和/或严重程度，但这些结果仍不确定。
目的和研究设计
在这项研究中，我们使用非侵入性可见和近红外（Vis-NIR）光谱技术，通过测量从患者鼻黏膜区域采集的水峰（970nm）光谱的变化，对甲型和乙型流感病毒感染引起的炎症反应进行比较分析。
结果
结果表明，乙型流感病毒感染引起的鼻黏膜区域炎症反应比甲型流感病毒更严重。
结论
这些是首次在病毒感染部位显示甲型和乙型流感病毒引起不同炎症反应的研究数据。
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