Laboratory of Cell Adhesion Dynamics - IRCC and Department of Oncological Sciences, University of Torino School of Medicine, 10060, Candiolo, Italy.
Curr Opin Cell Biol. 2012 Oct;24(5):582-91. doi: 10.1016/j.ceb.2012.08.004. Epub 2012 Sep 13.
The dynamic control of integrin-mediated cell adhesion to extracellular matrix proteins is crucial for several physiological and pathological phenomena as diverse as embryonic morphogenesis, muscle contraction, tissue repair, and cancer cell dissemination. On one hand, the intrinsic conformational plasticity of integrins, which can be bidirectionally modulated by their ligands and cytosolic adaptors in combination with physical forces, is a key regulatory parameter. On the other hand, endo-exocytic integrin traffic logistics represent an additional important mode of control. Herein, we highlight how these two apparently parallel and independent strategies for tuning integrin function appear instead to be indissolubly intermingled, as eukaryotic cells have evolved distinct molecular strategies and endosomal pathways to traffic ligand-bound and ligand-free integrins.
整合素介导的细胞与细胞外基质蛋白黏附的动态控制对于许多生理和病理现象都至关重要，如胚胎形态发生、肌肉收缩、组织修复和癌细胞扩散等。一方面，整合素的固有构象可塑性可以通过其配体和细胞质衔接蛋白与物理力的共同作用双向调节，这是一个关键的调节参数。另一方面，内吞-外排整合素运输物流则代表了另一种重要的控制方式。本文中，我们强调了这两种看似平行且独立的整合素功能调节策略是如何不可分割地交织在一起的，因为真核细胞已经进化出独特的分子策略和内体途径来运输配体结合和无配体的整合素。
