Gippsland Medical School, Northways Road, Monash University, Churchill, Victoria 3842, Australia.
J Clin Neurosci. 2012 Nov;19(11):1541-4. doi: 10.1016/j.jocn.2012.04.009. Epub 2012 Sep 13.
Medulloblastomas (MB) and primitive neurectodermal tumours (PNET) are known to affect children more than adults. To estimate the magnitude of the differences between the incidence of adults and children, the incidence rates, ratios and time trends of MB and PNET in children and adults are measured using data from the Surveillance, Epidemiology and End-Results (SEER) database. Between 1973 and 2007 in the SEER 9 registries, 1372 people were diagnosed with a MB and 530 with a PNET. The overall incidence rate of MB and PNET is approximately 1.5 and 0.62 per million population in the USA. Children (1-9 years of age) with MB had an incidence rate of 6.0, compared to 0.6 in adults, and therefore children are 10 times more likely to be affected by an MB than adults. Children are 4.6 times as likely to be afflicted by a PNET than adults. The difference in incidence rates based on sex existed only in children. Our study confirmed that the incidence rates of MB has not changed over time.
成神经管细胞瘤（MB）和原始神经外胚层肿瘤（PNET）多见于儿童，而儿童的发病率远高于成年人。为了评估成人和儿童发病率之间差异的幅度，我们利用监测、流行病学和最终结果（SEER）数据库的数据，对儿童和成人群体中 MB 和 PNET 的发病率、比例和时间趋势进行了测量。在 1973 年至 2007 年间的 SEER9 注册中心，有 1372 人被诊断为 MB，530 人被诊断为 PNET。在美国，MB 和 PNET 的总体发病率约为每百万人口 1.5 和 0.62。儿童（1-9 岁）的 MB 发病率为 6.0，而成年人的发病率为 0.6，因此儿童患 MB 的可能性是成年人的 10 倍。儿童患 PNET 的可能性是成年人的 4.6 倍。这种发病率上的差异仅存在于儿童群体中。我们的研究证实，MB 的发病率并未随时间而改变。
