[阿尔及利亚人群中的易感性基因、HLA与糖尿病视网膜病变]
[Susceptibility genes, HLA and diabetic retinopathy in the Algerian population].
作者信息
Raache R, Hennachi R, Amroune H, Heniche A, Belanteur K, Benyahia A, Ouandjeli K S, Barar A, Houhou D, Mimouni S, Gervais T, Latinne D, Boudiba A, Attal N, Abbadi M C
机构信息
Laboratoire de biologie cellulaire et moléculaire, faculté des sciences biologiques, université des sciences et de la technologie, Houari Boumediene, Bab Ezzouar, Alger, Algérie.
出版信息
J Fr Ophtalmol. 2013 Mar;36(3):247-54. doi: 10.1016/j.jfo.2012.01.008. Epub 2012 Sep 14.
BACKGROUND
Diabetic retinopathy (DR) is the most frequent microvascular complication of type I diabetes (T1D). Some well-controlled type I diabetics may develop DR, while other poorly-controlled diabetics do not develop DR. This might be explained by certain susceptibility genes or protective genes. The purpose of our study is to search for any association between the HLA class I and II markers and DR in the Algerian population.
PATIENTS AND METHODS
This study was carried out in 52 T1D subjects with and without DR compared to 140 healthy controls. HLA typing was performed using the "microlymphocytotoxicity" technique.
RESULTS
The frequency of HLA-A29 and HLA-DR9 antigens is higher in T1D with DR compared to T1D without DR and to controls with frequencies of HLA-A29 (59.26% vs. 0%, OR=∞, pc=4.6×10(-7)), (59.26% vs. 5.66%, OR=24.24, pc=7.6×10-10) and HLA-DR9 (29.63% vs. 0%, OR=∞, pc=1.310(-3)), (29.63% vs. 4.29%, OR=9.40, pc=7.010(-5)) respectively. However, the frequency of HLA-B49 antigen is significantly lower in T1D with DR than in T1D without DR (3.7% vs. 28%, OR=0.10, pc=8.8×10(-3)) and compared to controls (3.7% vs. 22.64%, OR=0.13, pc=0.011).
CONCLUSION
HLA-A29 and HLA-DR9 antigens are probably markers of susceptibility for DR while HLA-B49 antigen is probably associated with a protective effect in the Algerian population.
背景
糖尿病视网膜病变（DR）是1型糖尿病（T1D）最常见的微血管并发症。一些血糖控制良好的1型糖尿病患者可能会发生DR，而其他血糖控制不佳的糖尿病患者却未发生DR。这可能由某些易感基因或保护基因来解释。我们研究的目的是在阿尔及利亚人群中寻找HLAⅠ类和Ⅱ类标记物与DR之间的任何关联。
患者与方法
本研究纳入了52例患有和未患有DR的T1D患者，并与140名健康对照者进行比较。采用“微量淋巴细胞毒性”技术进行HLA分型。
结果
与无DR的T1D患者及对照组相比，伴有DR的T1D患者中HLA - A29和HLA - DR9抗原的频率更高，HLA - A29的频率分别为（59.26%对0%，OR = ∞，pc = 4.6×10(-7)），（59.26%对5.66%，OR = 24.24，pc = 7.6×1⁰⁻¹⁰），HLA - DR9的频率分别为（29.63%对0%，OR = ∞，pc = 1.3×10(-3)），（29.63%对4.29%，OR = 9.40，pc = 7.0×10(-5)）。然而，伴有DR的T1D患者中HLA - B49抗原的频率显著低于无DR的T1D患者（3.7%对28%，OR = 0.10，pc = 8.8×10(-3)），与对照组相比也较低（3.7%对22.64%，OR = 0.13，pc = 0.011）。
结论
在阿尔及利亚人群中，HLA - A29和HLA - DR9抗原可能是DR的易感标记物，而HLA - B49抗原可能具有保护作用。
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