Dahan Nili, Choder Mordechai
Department of Molecular Microbiology, Technion-Israel Institute of Technology, Haifa, Israel.
Biochim Biophys Acta. 2013 Jan;1829(1):169-73. doi: 10.1016/j.bbagrm.2012.08.004. Epub 2012 Sep 6.
In eukaryotes, nuclear mRNA synthesis is physically separated from its cytoplasmic translation and degradation. Recent unexpected findings have revealed that, despite this separation, the transcriptional machinery can remotely control the cytoplasmic stages. Key to this coupling is the capacity of the transcriptional machinery to "imprint" the transcript with factors that escort it to the cytoplasm and regulate its localization, translation and decay. Some of these factors are known transcriptional regulators that also function in mRNA decay and are hence named "synthegradases". Imprinting can be carried out and/or regulated by RNA polymerase II or by promoter cis- and trans-acting elements. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
在真核生物中，细胞核内的mRNA合成在空间上与细胞质中的翻译和降解过程相分离。最近一些出人意料的发现表明，尽管存在这种分离，转录机制仍能远程控制细胞质中的各个阶段。这种偶联的关键在于转录机制能够用一些因子“印记”转录本，这些因子护送转录本进入细胞质并调节其定位、翻译和降解。其中一些因子是已知的转录调节因子，它们也在mRNA降解中发挥作用，因此被称为“合成降解酶”。印记过程可以由RNA聚合酶II或启动子顺式和反式作用元件进行和/或调节。本文是名为“RNA聚合酶II转录延伸”的特刊的一部分。
