Epigenetic changes brought about by perinatal stressors: a brief review of the literature.
作者信息
Billack Blase, Serio Ryan, Silva Ilton, Kinsley Craig H
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Jamaica, NY 11439, USA.
出版信息
J Pharmacol Toxicol Methods. 2012 Nov-Dec;66(3):221-31. doi: 10.1016/j.vascn.2012.08.169. Epub 2012 Sep 6.
INTRODUCTION
Numerous studies employing various animal models have found that perinatal stress, encountered in utero during sensitive developmental stages or shortly after birth, disrupts both sexual differentiation and sexual behavior in offspring. The biochemical, cellular, genetic and epigenetic events which are involved in the organismal response to perinatal stress are currently under investigation.
METHODS, RESULTS AND DISCUSSION: In this review, the reader is introduced to perinatal stressors as a toxicological phenomenon, and several recently characterized epigenetic responses to said stressors are discussed.
Zotero 插件