Wee1-Hsp90 inhibitor combination treatment: molecular therapy with potentially broad applicability.
作者信息
Lokeshwar Vinata B
机构信息
Division of Urology Research, Department of Urology and Cell Biology, University of Miami Miller School of Medicine, Miami, FL, USA.
出版信息
Cell Cycle. 2012 Oct 15;11(20):3722-3. doi: 10.4161/cc.22119. Epub 2012 Sep 14.
Abstract
摘要
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本文引用的文献
1
Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells.联合抑制 Wee1 和 Hsp90 可激活癌细胞中的内在凋亡。
Cell Cycle. 2012 Oct 1;11(19):3649-55. doi: 10.4161/cc.21926. Epub 2012 Aug 30.
2
Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.影响热休克蛋白 90 靶向治疗的肿瘤内在和外在因素。
Curr Mol Med. 2012 Nov 1;12(9):1125-41. doi: 10.2174/156652412803306729.
3
High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy.Wee1 高表达与恶性黑色素瘤无病生存不良相关：潜在的靶向治疗。
PLoS One. 2012;7(6):e38254. doi: 10.1371/journal.pone.0038254. Epub 2012 Jun 12.
4
Hsp90 inhibitors and drug resistance in cancer: the potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs.热休克蛋白 90 抑制剂与癌症耐药性：联合应用热休克蛋白 90 抑制剂和其他抗癌药物的潜在治疗益处。
Biochem Pharmacol. 2012 Apr 15;83(8):995-1004. doi: 10.1016/j.bcp.2011.11.011. Epub 2011 Nov 22.
5
MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells.MK1775，一种选择性的 Wee1 抑制剂，对肉瘤细胞具有单药抗肿瘤活性。
Mol Cancer Ther. 2012 Jan;11(1):174-82. doi: 10.1158/1535-7163.MCT-11-0529. Epub 2011 Nov 14.
6
Hsp90 phosphorylation, Wee1 and the cell cycle.Hsp90 磷酸化、Wee1 和细胞周期。
Cell Cycle. 2010 Jun 15;9(12):2310-6. doi: 10.4161/cc.9.12.12054.
7
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.Swe1Wee1 依赖性酪氨酸磷酸化调节热休克蛋白 90 的伴侣功能的不同方面。
Mol Cell. 2010 Feb 12;37(3):333-43. doi: 10.1016/j.molcel.2010.01.005.
8
Phosphotyrosine confers client specificity to Hsp90.磷酸酪氨酸赋予热休克蛋白 90 以客户特异性。
Mol Cell. 2010 Feb 12;37(3):295-6. doi: 10.1016/j.molcel.2010.01.028.
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